Research Papers from the Kumar Lab


Baker, L.R., Weasner, B.M., Nagel, A., Neuman, S.D., Bashirullah, A., and Kumar, J.P. (2018) Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium. Development 145(15): dev163329 (PMCID: PMC6110151)


Zhu, J., Ordway, A., Weber, L., Buddika, K., and Kumar, J.P. (2018) Polycomb group (Pc-G) proteins and Pax6 cooperate to inhibit in vivo reprogramming of the developing Drosophila eye. Development 145(7):dev160754


Palliyil, S., Zhu, J., Baker, R., Neuman, S.D., Bashirullah, A., and Kumar, J.P. (2018) Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks. PLoS Genetics 14(1): e1007185 (PMCID: PMC5792024)


Zhu, J., Palliyil, S., Ran, C., and Kumar, J.P. (2017) Drosophila Pax6 promotes development of the entire eye-antennal disc thereby ensuring proper adult head development. PNAS 114(23): 5846-5833


Weasner, B.M., Weasner, B.P., Neuman, S.D., Bashirullah, A., and Kumar, J.P. (2016) Retinal expression of the Drosophila eyes absent gene is controlled by several cooperatively acting cis-regulatory elements. PLoS Genetics 12(12):e1006462


Iyer, J., Wang, Q., Le, T., Pizzo, L., Gronke, S., Ambegaokar, S.S., Imai, Y., Srivastava, A., Troisi, B.L., Mardon, G., Artero, R., Jackson, G.R., Isaacs, A.M., Partridge, L., Li, B., Kumar, J.P., and Girirajan, S. (2016) Quantitative assessment of eye phenotypes for functional genetic studies using Drosophila melanogaster. G3: Genes, Genomes, and Genetics 6: 1427-1437


Spratford, C.M. and Kumar, J.P. (2015) Inhibition of Daughterless by Extramacrochaetae mediates Notch induced cell proliferation. Development 142: 2058-2068


Spratford, C.M. and Kumar, J.P. (2015) Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs. Development 142: 1006-1015


Spratford, C.M. and Kumar, J.P. (2014) Dissection of imaginal discs from Drosophila melanogaster. J. Vis. Exp. 91: e51792 doi:10.3791/51792


Spratford, C.M. and Kumar, J.P. (2014) Hedgehog and Extramacrochaetae in the Drosophila eye: an irresistible force meets an immovable object. Fly 8: 36-42


Anderson, A.M., Weasner, B.P., Weasner, B.M. and Kumar, J.P. (2014) The Drosophila Wilms’ Tumor 1-Associating Protein (WTAP) homolog is required for eye development. Developmental Biology 390: 170-180


Spratford, C.M. and Kumar, J.P. (2013) Extramacrochaetae imposes order on the Drosophila retina by refining the activity of the Hedgehog signaling gradient. Development 140: 1994-2004


Weasner, B.M. and Kumar, J.P. (2013) Competition among gene regulatory networks imposes order within the eye-antennal disc of Drosophila. Development 140: 205-215


Lubbering, N., Charlton-Perkins, M., Kumar, J.P., Lochhead, P.A., Rollmann, S.M., Cook, T., and Cleghon, V. (2013) Drosophila Dyrk2 plays a role in the development of the visual system. PLoS One 8(10):e92344


Anderson, A.M., Weasner, B.M., Weasner, B.P. and Kumar, J.P. (2012) Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development. Development 139: 991-1000


Datta, R., Weasner, B.P. and Kumar, J.P. (2011) A dissection of the Teashirt and Tiptop genes reveals a novel mechanism for regulating transcription factor activity. Developmental Biology 360: 391-402


Datta, R., Cruckshank, T. and Kumar J.P. (2011) Differential selection within the Drosophila retinal determination network and evidence for functional divergence between paralog pairs. Evolution & Development 13:1: 58-71


Salzer, C.L., Kumar, J.P. (2010) Identification of Retinal Transformation Hot Spots in Developing Drosophila Epithelia. PLoS ONE 5: 1-8


Salzer, C.L., Elias, Y. and Kumar, J.P. (2010) The retinal determination gene eyes absent is regulated by the EGF Receptor pathway throughout development in Drosophila. Genetics 184: 185-197


Weasner, B.M., Weasner, B.P., DeYoung, S.M., Michaels, S.D. and Kumar, J.P. (2009) Transcriptional activities of the Pax6 gene eyeless regulate tissue specificity of ectopic eye formation in Drosophila. Developmental Biology 334: 492-502


Weasner, B.P. and Kumar, J.P. (2009) The Non-Conserved C-Terminal Segments of Sine Oculis Homeobox (SIX) Proteins Confer Functional Specificity. Genesis 47: 514-523


Datta, R.R., Lurye J.M., and Kumar, J.P. (2009) Restriction of Ectopic Eye Formation by Drosophila Teashirt and Tiptop to the Developing Antenna. Developmental Dynamics 238:2202-2210


Salzer, C.L. and Kumar, J.P. (2009) Position Dependent Responses to Discontinuities in the Retinal Determination Network. Developmental Biology 326: 121-130


Avadhanula, V., Weasner, B.P., Hardy, G.G., Kumar, J.P. and Hardy, R.W. (2009) A novel system for the launch of alphavirus RNA synthesis reveals a role for the Imd pathway in arthropod antiviral response. PloS Pathogens 5:1-12


Yao, J.G., Weasner, B.M., Wang, L.H., Jang, C.C., Weasner, B.P., Tang, C.Y. Salzer, C.S., Chen, C.H., Sun, Y.H. and Kumar, J.P. (2008) Differential Requirements for the Pax6(5a) Genes eyegone and twin of eyegone During Eye Development in Drosophila. Developmental Biology 315: 535-551


Weasner, B., Salzer, C. and Kumar, J.P. (2007) Sine oculis, a Member of the Six Family of Transcription Factors Directs Eye Formation. Developmental Biology 303: 756-771


Anderson, J.L., Salzer, C. and Kumar, J.P. (2006) Regulation of the Retinal Determination Gene dachshund in the Embryonic Head and Developing Eye of Drosophila. Developmental Biology 297: 536-549


Anderson, J. L., Bhandari, R. and Kumar, J. P. (2005) A Genetic Screen Identifies Putative Targets and Binding Partners of CREB Binding Protein (CBP) in the Developing Drosophila Eye. Genetics 171: 1655-1672


Roederer. K., Cozy, L., Anderson, J. and Kumar, J.P. (2005) A Novel Dominant Negative Mutation within the Six Domain of the Conserved Eye Specification Gene sine oculis Inhibits Eye Development in Drosophila. Developmental Dynamics. Developmental Dynamics 232:753-766


Kumar, J.P., Jamal, T., Doetsch, A., Turner, F.R. and Duffy, J.B. (2004) CREB Binding Protein (CBP) Functions at Successive Stages of Eye Development in Drosophila. Genetics 168:877-893

Previous Research Papers

Kumar, J.P., Hsiung, F., Powers, M.A. and Moses, K. (2003) Nuclear Translocation of Activated MAP Kinase is Developmentally Regulated in the Developing Drosophila Eye. Development 130:3703-3714

Kumar, J. P., Moses, K. (2001) EGF Receptor and notch Signaling Act Upstream of Eyeless/Pax6 to Control Eye Specification. Cell 104:687-697

Kumar, J. P., Moses, K. (2001) The EGF Receptor and notch Signaling Pathways Control the Initiation of the Morphogenetic Furrow During Drosophila Eye Development. Development 128:2689-2697

Kumar, J. P., Moses, K. (2001) Expression of Evolutionarily Conserved Eye Specification Genes During Drosophila Embryogenesis. Development, Genes and Evolution 211:406-414

Kumar, J. P., Wilkie, G. S., Tekotte, H., Moses, K., Davis, I. (2001) Perturbing Nuclear Transport in Drosophila Eye Imaginal Disc Causes Specific Cell Adhesion and Axon Guidance Defects. Developmental Biology 240:315-325

Kumar, J. P., Tio, M., Hsiung, F., Akopyan, S., Gabay, L, Seger, R., Shilo, B. Z., Moses, K. (1998) Dissecting the Roles of the Drosophila EGF Receptor in Eye Development and MAP Kinase Activation. Development 125:3875-3885

Kumar, J. P., Bowman, J., O’Tousa, J. E., Ready, D. F. (1997) Rhodopsin Replacement Rescues Photoreceptor Structure During a Critical Developmental Window. Developmental Biology 188:43-47

Kumar, J. P., Ready, D. F. (1995) Rhodopsin Plays an Essential Structural Role in Drosophila Photoreceptor Development. Development 121:4359-4370

Fryxell, K. J., Kumar, J. P. (1993) Characterization of the Radiation-Sensitive Stage in the Development of the Compound Eye of Drosophila. Mutation Research 285:181-189

Fryxell, K. J., Kumar, J. P., Johnson, J. L. (1992) A Rapid and Efficient Method of Subcloning into Transformation Vectors. BioTechniques 13:28-30

Fryxell, K. J., Wood, C. P., Kumar, J. P. (1992) Improved Procedures for P-Element-Mediated Transformation of Drosophila melanogaster. Drosophila Information Service 71:163